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While I don't have all that big an engine, I can answer some of your q's.
1. engine towers/motor mounts
Simple, get stock big block pieces. There are 2 typews, the 68 - 71, and then there are 72. You will pay a butt load either way, the 68 - 71 mounts are expensive, but the frame mounts are dirt cheap. The 72 units are the other way around. Cheap mounts, and expensive on the frame mounts. Personally I'd get the 72 style. Pay once instead of every time you rip a motor mount.
2.driveshaft
Never heard of anyone really havin problems. You could talk to your local drive shaft repair place and see what they can do for you. Being a SWB you can get a one piece shaft with absolutly no problems at all.
3.Rear end (I have a car 12 bolt with Moser axles, etc...)
The car 12 bolt is nothing like the truck 12 bolt. While there are other units out there stronger, i have personally seen a 67 LWB doing 12's in the 1/4 mile with slicks (actually just one slick) and hardly any wheel spin. This was also his daily driver (only vehicle) and he never had any problems.
4. Frame flex/twist under heavy accerlation causing cab/body distortion
Again, i have never personally seen nor heard anything along these lines. There will be some, but being a truck it is kinda made for more abuse than a typical car frame.
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