For a non-performance truck, besides the SM465, I would probably only do the necessary mods to install an NV4500, 5 spd. However, I would convert to an aftermarket hydraulic clutch setup. Then move trans bracket and deal with altering the driveshaft. My current pickup came with a SM465, but I only use it tow and hopefully soon to convert to 4x4.
I've owned a couple of trucks that had SM465's. If getting a used one, I would try to test drive it first. The only problems I've seen is the synchros going and the tranny popping out of gear, unless the shifter was manually held in place. are usually easy to find and fairly cheap. Just a little on the heavy side. One person can install them without a jack though. You can make other trannies work, but you said the "easiest swap." Which also most likely would be the cheapest as well.
edit... Here is another recent post.
http://67-72chevytrucks.com/vboard/s....php3?t=136923