There are a lot of variables...
The condensation that builds up in the engine from the humidity in the air will burn off much slower with the 160 degree stat, however, most engine dyno sheets I've seen make more power at lower eng. temps. (which is why the hyper chips recomend the 160 stat) Lower engine temps can let you run cheaper fuel...lower grade of fuel anyways. The hotter the engine, the more likely it is to have preignition issues.
I say try it and see what you observe. In my case, I hardly ever take trips long enough to bring the engine to 200+, so the benifit of burning off the water was a moot point, so i ran the lower t-stat in the summer. The 20 degree differance was enough in the winter though, that my heater didn't work for squat.
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