The 6.0L has a 4L80E, and like almost every fullsize out here, it is a 4x4.
I've been looking closely at the wiring on my father's 06, and if the 01 is similar, I think that things should work out fairly reasonably easily. I do believe the 01 will still have a throttle cable, and should have the sweet aluminum heads as well.
My only real concerns for swapping it in would be how to get my SM465 bolted to it and working right off the batt, getting the PCMs flashed and exhaust. I can probally re-work most of the harnesses myself so long as I've got a few diagrams
We'll just have to see how much that 6.0L and all the wiring would set me back before I leap into anything.
As you mentioned N2TRUX, the number 1 biggest advantage of running the 6.0L over the 5.7L TPI is that I will have zero tuning to do on it. Just run a standard transmission binary, and I should be good to go!