For the front, go with spindles for a 2.5" drop...add springs to that if you want to go lower.
For the rear...lowering blocks work if your axle rests on the suspension, rather than hanging from it...i.e. if you flipped the axle so it rides on top of the leaf springs (assuming a leaf spring truck, and that's about a 4" drop on it's own from what I hear), if you added a block between the axle and the spring, it would lower the truck.
I don't know if lowering blocks work on coil trucks, I don't have a good enough mental picture of the trailing arm setup to know whether the axle hangs from or rests on the arms.
Either way, I think you'd be better off with some drop springs; 4" is a good number to go with 2.5" up front, IMO. It's only what my '70 GMC has, after all.