If you have one of the Rochester series you will want to change out your float to a brass float. (Pic 1) Also, you will have issues in cold weather. I highly suggest converting your choke from thermal or auto to a manual choke cable that you can manually adjust. The first thing you will notice after a full tank of E85 is that your fuel filter will be completely clogged. Get an inline fuel filter (the larger the better, I personally like the Wix O'Reilly part number 33033) and keep a spare or 3 in your glove box. Change out any rubber part that you can with something that is E85 safe. When you take the plunge start out with a gallon of E85 and a gallon of Premo. Have a 5 gallon spare tank of premo to get you home if you have issues. The choke has been the only issue I have had since.
Rebuild of my Rochester carb
here.
Pic 1. Take note of what the E85 did to that poor bake-o-lite float. (it now sinks in regular octane).