With a MII front end my SMC fits in nice and low. It has a tubular mount welded to the frame and stock mounts bolted to the block. With a 700r4 I didn't need to make a custom hump in the floor either. I still have 19" from the top of the heads to the bottom of the hood, just incase you want to mount a stealth blower or velocity stacks! My stock frame takes my motors 275hp easily but if you looking for more, I would box the frame.
If your considering costs of your buid the S10 is a good way to go Dollar $$ wise. A MII front end is about $2000 by the time it's installed and your complete S10 frame costs what? $200. With the other $1800 I would invest in a 4 link rear, tubular A arms, etc. Of course the S10 isn't exactly a bolt on swap but it's been done here enough and there's plenty of help for you.