I did it last month for some 1,100 miles from Kansas to Pennsylvania.
Just make sure you get a dolly wide enough, mine was barely, if you notice that it has no fenders (had to take'em off to get more clearence) and the blazer's tires were about 2 inches on both sides from the dolly tires, but I made it.
I don't think that you have to take the driveshaft off; I did, mine's auto, your blazer being manual just put it in neutral.
I'm guessing your blazer is also 2wd.