Your going to need a 2wd donor to make it happen, but yes it can be done. There are a couple of holes here and there that may need to be drilled or elongated, but I can't remember all of them.
I had a buddy that went from 4wd to 2wd, then a few years laer he is going back to 4wd. He is getting his use out of his Blazer....:p
They do kinda grow on ya, don't they...