I put a world class T5 in my 74 C10 about 10 years ago and have logged over 60,000 miles on it. Great transmission. Heres the deal,
You need a T5 from a V8 Camaro/Firebird. Mine came out of a 1990 Fbody. I used the bellhousing from the Camaro as well. This will mount the trans at a 17 degree angle but its not a problem. The trans mount is about 3 inchs further back than a turbo 350 so I just slid my crossmember back and drilled new holes in the frame to mount it. You can use the camaro slave cylinder and a clutch master cylinder and pedal assembly from a 87 C10. Use the camaro clutch/pressure plate and flywheel. Hope that your crank is machined for a pilot bearing. (some are not)
For the shifter I used the mounting plate from the camaro shifter and the guts from a ford mustang T5. This gave me a shorter throw and the mustang handle/stick is a bolt on the same as a Hurst so I used a 17 inch Hurst handle and bent it to make up for the 17 degree mounting angle of the trans. This put the handle perfectly straight through the floor in the same spot as the muncie 4-speed I had before.
Same driveshaft yoke as a turbo 350/muncie but had to shorten the driveshaft about 3 inchs.
As far as the S10 V6 T5, It has a different input spline (14 spline IIRC) and uses a 10 inch clutch which wont work with a 350 V8. I think advanced adapters makes a clutch assembly to swap a V8 in a S10 but it is pricey. Also the S10 T5 has a very low first gear and is not well suited for V8 use. The camaro trans is ideal and plenty strong as long as you don't drag race it.
Don't put gear oil in it (they use ATF) and it will last many years. Mine already had 90,000 miles on it when I pulled it and I added over 60,000 and it still works great.
Thats about all I can think of. Hope this helps.
Good luck!!