I used a 19x22 in my last build on this truck, with a 4.3. I'm in the process of putting a 5.3 in it right now and also exploring radiator options. Have you done any mocking up yet? Are you planning on buying a new thermostat housing? Also you'll want to look for a radiator with the smaller, LS sized necks (1.5 "lower, 1.25" upper).
Here's a mock-up picture with my old 19x22:
Here's how the original water neck orientation: