No, it shouldn't. Causes of misfires are bad plugs, even the spark plug wires can cause a misfire if the covering is stripped or worn in places, sticky valves, weak valve springs, burnt points(usually it won't even start), a flat cam could be a possibility, did you check your compression? Burnt valves or worn valves will cause a misfire or constant popping. You can check if you have issues with the head by compression; if all is even then you might have weak springs or ignition issues, if your compression is much lower in some cylinders then you have valve issues or piston ring issues.
