For some reason I read it that he wanted a vortec "long-block" and to keep the TBI; after rereading the OP, not sure where I got that
So yes completely different wiring, fuel delivery, etc.
The only thing I think you would save going vortec 5.7 vs. 5.3, is engine mounts, and manifolds/headers and exhaust mod.
I have seen people asking silly $ for a high-mile 5.7, and I have seen some pretty cheap LS engines, that part might be a wash.