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OK. With the engine not running, you should screw both mixture screws in till they bottom, then back them out whatever the specification calls for on your application. They should be backed out equally. After that, and with the timing and idle speed set to specs, you do a fine tune on both mixture screws. If you do not have to go through smog check, just set them for highest idle speed, then adjust idle down to speck and repeat the process.