Re: 4L80E Cooler line size 3/8" or 5/16"
In general for almost any automotive system; bigger lines can be used in place of smaller lines (fuel, oil, trans, coolant etc). Smaller (narrower) lines in almost any of those systems will create a restriction point, and depending on which system, will have different negative effects; cavitation, reduced flow, increased pressure where pressure is not desired, foaming, increased heat.
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'66 Short Step / SD Tuned / Big Cam LQ4 / Backhalfed /Built 4l80e / #REBUILDEVERYTHING 
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