I would not say the single stage or base coat clear is easier to spray. They are the same its just with base coat you spray clear separately. I can only think of one reason to use single or base coat or vise versa, that is metallic vs. non metallic. If you are doing a solid color single stage is a great way to go, but single stage metallic is a pain to get the metallic to lay down correctly and you can forget about touch ups being easy on a single stage metallic. Imo solid colors could be either single stage or base coat / clear coat (You can also clear over single stage to add more gloss) but metallic is way easier with base coat clear.
Spraying is the easiest part of the paint job, if your technique is decent, it really does not matter what you are shooting as far as base coat / clear or single stage. Even then runs and trash issues can be fixed. The hardest part of getting a nice paint job is the bodywork and prep.
As far as blending this is where base coat clear shines imo, touch up are easier also. Here is a panel I had to blend after I made changes to the firewall.
