The LQ4 6.0L is noticeably less fuel efficient than the LM7 5.3L
The stock LQ4 is 330hp and 370ft-lb of torque.
https://www.onallcylinders.com/2018/...ads-cam-specs/
The stock LM7 is 295hp and 335ft-lb of torque.
https://www.onallcylinders.com/2018/...ads-cam-specs/
The stock LR4 is 280hp and 295ft-lb of torque.
https://www.onallcylinders.com/2019/...ads-cam-specs/
There's no replacement for displacement but you will pay for it in fuel. The LM7 5.3L typically runs mid to high teens highway mileage. My 6.0 runs 12-12.5 highway.
The lower displacement engines will need to turn significantly more RPMs to generate the HP numbers the bigger engine will generate at low RPMs.
Comparing the LS4 5.3L in my 2009 Impala SS to the 3.6L in my 2012 Impala LTZ is a good case study. My bone stock SS will spank the LTZ off the line and continue to do so all the way to the 1/4 mile. They come in at roughly the same 300ish HP numbers but the LS4 will shove you back in your seat from a dead stop while the 3.6L needs to be wound way up before it begins to wake up. By the time my LTZ is tached up it's playing catch up for the whole stretch. The 5.3L SS has run a 13.98 and the 3.6L LTZ did 14.74 seconds. Close but no cigar.
My Front Wheel Drive Aluminum LS4 5.3L actually gets higher mileage than the tuck motors. 24 highway and 19 in town. Lighter vehicle and lighter engine. I looked into cramming an LS4 out of a wreck into a 1980s S10 in place of a 90° V6. The LS4 is a Gen IV with the 60° FWD V6 bellhousing bolt pattern and FWD motor mounts so it's really not straightforward to put one in a longitudinal engine bay. Not to mention that the ECM/TCM combo wouldn't like manual transmissions.