Advice on 250 6 cylinder build

[Runner76]

As part of my 77 C-10 project, I will be rebuilding the original 250 engine. In addition to the normal overall, I want to up the performance factor. I am thinking head work to increase compression to 9 to 1, three angle valve job, aftermarket cam, carb upgrade and headers. Has anyone done something similar? I realize dropping in a small block would be easier, but I want to do something a little different. Any thoughts or advise/suggestions? Would the results justify the effort and expense?
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