ECM and 4wd to 2wd swap

[67pete300]

I'm looking for an entire donor vehicle (nominally LM7/4L60e) for my 65 C10.

There are many more 4x4 vehicles out there and in my price range are higher mileage that probably need a trans rebuild anyway.

I've read about trying to get compatible engines and transmissions, but why can't I just buy a 4x4 donor vehicle and trade the 4wd 4L60 in for a rebuilt 2wd version?

Does this present compatibility issues that can or cannot be fixed with the ECM reflash?

Ultimately this is the same question I guess for just buying a standalone engine and trying to find the correct transmission to mate up.

I'm not interested in converting the 4x4 transmission to 2wd.