Vortec and 4 L80E Swap

[85blacklong]

I have access to a bone stock running and driving L31 5.7 and 4L80E from a 2000 GMC that I want to swap into my 1985 C10. My current 305 is a boat anchor! This is a low budget build but I want it to be dependable. I am not looking to set any land speed records.
Can I swap the motor & trans using the factory harness? I plan to eliminate all the emissions crap and have the computer flashed. I was told to ditch the factory fuel injection and go to a Holley Sniper with a stand alone harness for the trans.
Please advise as to what my best and most dependable options are.
Thank you in advance!