The 63-66 trucks used the 250. Most of the trucks had manual trannys in them, so you will have to consider transmission linkage and probably drive shaft. The exception would be a 292 six which has it's motor mount tower in a different location. You could even use a V8, then you will have to reroute the engine wiring harness. Hope this helps.
Larry
68 C20 327 daily driver
63 C20 292 Camper truck
65 C10 ? Custom Cab AC,PB,PS,$flasher
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