paint reaction please help ???

[Tycoon4u]

I painted the top of my cab w/white oil based enamal and found 1 goobered spot on the window post. I sanded it smooth but every time I try to primer the small bare metal spots it softens and blisters the white paint. I've tried both enamal and laquer primer. The white goes on fine over the dry primer but when I spray primer over the bare spots it reacts with the white next to it while wet. Any input would be appreciated.

thanks, Dale